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Research

Many of our faculty maintain laboratories and staff to perform both basic and clinical research projects. Often these studies are funded by the National Institute of Health (NIH) and the National Science Foundation (NSF). Other research is supported by groups like the National Cancer Institute or the American Heart Association. Our researchers follow strict safety guidelines, protect patient confidentiality, and must meet standards imposted by the Federal Government, State Government, University Committees, and peer-reviewed boards.

The main themes of the research in our department are: 1) degenerative neurological diseases, 2) cancers, 3) tissue injury, inflammation and infection, and 4) metabolic disturbance and stem cell.  The department’s research in Alzheimer’s disease is represented by the group led by  Dr. Bernadino Ghetti, who is an internationally renowned neuropathologist and researcher in Alzheimer Disease . Dr. Ghetti is also  the Director of the Indiana Alzheimer Disease Center (IADC), which has been funded by National Institute on Aging (NIA) since 1991 and is one of the 29  Alzheimer Disease Research Centers established by NIA nationally. Many faculty in the department are involved in cancer related research that extend to lung cancer, liver cancer, genito-urinary track cancer (prostate cancer, germ cell cancer and ovarian cancer), and breast cancer.  Our research has been broadly involved in the understanding of the molecular mechanism of cancer biology, in the establishment of better pathology diagnosis and in the development of novel cancer therapy.  Metabolic disturbance as represented by obesity, hepatic steatosis, type II diabetes and insulin resistance have rapidly become a major health concern in this country and worldwide.  There is still much to be learned regarding the pathogenesis and clinical management of metabolic disturbance.  Notably tissue injury, inflammation and infection, as well as cell death, has been well connected to neurodegeneration, cancer and metabolic disturbance.  The research in this area will be important for a better understanding of the disease and development of effective treatment using novel approaches such as stem cells.

This list shows the research projects of some of our faculty members:

i. Degenerative Diseases

Bernardino Ghetti, MD
Barbara Kluve-Beckerman, PhD
Merrill D. Benson, MD
Jill R. Murrell, PhD
Ruben G. Vidal, PhD

ii. Cancer

Sunil S. Badve, MD
Liang Cheng, MD
Hong Du, PhD
John N. Eble, MD, MBA
Raymond L. Konger, MD
George Sandusky, DVM, PhD
Thomas M. Ulbright, MD
Cong Yan, PhD
Xiao-Ming Yin, MD, PhD

iii. Tissue injury, inflammation and infection

Thomas E. Davis, MD, PhD
Hong Du, PhD
Raymond L. Konger, MD
Chao-Hung Lee, PhD
Xiao-Ming Yin, MD, PhD

iv. Metabolic Disturbance

Xiao-Ming Yin, MD, PhD

 

This list shows the campus wide core facilities run by the pathology faculty:

Immunohistochemistry Core (led by Dr. Hattab Eyes)
Neuropathology Core (led by Dr. Bernadino Ghetti)
Specimen Storage Facility at Indiana Clinical and Translational Sciences Institute (led by Dr. George Sandusky)
Tissue Procurement and Distribution at Simon Cancer Center (led by Dr. George Sandusky)
Translational Genomics at Simon Cancer Center (led by Dr. Sunil Badve)

Other useful links


Research in the News

Dept. of Pathology & Laboratory Medicine Administration Office | Van Nuys Medical Science Building | 635 Barnhill Drive, room A-128 | Indianapolis, IN 46202 Indiana University Health Pathology Laboratory: 350 W. 11th Street, Indianapolis, Indiana 46202