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Bernardino Ghetti, MD

Distinguished Professor of Neuropathology
Distinguished Professor of Pathology and Laboratory Medicine
Indiana University School of Medicine
Director, Indiana Alzheimer Center
Clarian Pathology Laboratory
350 West 11th Street, Room 4034
Indianapolis, IN 46202-4108

Telephone: 317-491-6360
FAX: 317-274-4882
email: bghetti@iupui.edu

Over the past 25 years, I have been studying hereditary neurodegenerative diseases of mice and men. My colleagues and I have expertise in neuropathology, biochemistry, and molecular genetics as well as cellular and molecular biology; these disciplines and the relevant techniques are used in a multidisciplinary approach to our research.

We have been focusing on the biology of hereditary dementing disorders, including Alzheimer disease, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and Pick disease. Our studies of kindreds with dementia inherited in an autosomal dominant pattern have resulted in the identification of novel mutations in the Amyloid Precursor Protein, Presenilin 1, Prion Protein, and Tau genes. In addition, we have characterized the clinical, neuropathologic and biochemical phenotypes associated with specific mutations. We also have a long-standing involvement with the analysis of the biology of cell death in neurological mutant mice.

Our current efforts are directed toward the identification, characterization and classification of new forms of dementia and the associated genetic defect. In addition, we are involved in the development and analysis of transgenic mouse models. Clinical and research efforts are funded by multiple grants from the Nation Institutes of Health and the Alzheimer's Association and we have one of the 28 Alzheimer disease centers funded by the National Institute on Aging.

Publications:

  1. Vidal, R.; Ghetti, B.; Takao, M.; Uro-Coste E.; Glazier, B.S.; Siani, V.; Benson, M.D.; Calvas, P.; Miravalle, L.; Rscol, O.; Delisle, M.B. Hereditary Ferritinopathy: A novel neurodegenerative disease associated with a mutation in the Ferritin Light Polypeptide gene and intra cellular ferritin deposition in multiple organ systems. Journal of Neuropathology and Experimental Neurology. (Submitted)
  2. Baba Y. Tsuboi Y. Baker MC. Uitti RJ. Hutton ML. Dickson DW. Farrer M. Putzke JD. Woodruff BK. Ghetti B. Murrell JR. Boeve BF. Petersen RC. Verpillat P. Brice A. Delisle MB. Rascol O. Arima K. Dysken MW. Yasuda M. Kobayashi T. Sunohara N. Komure O. Kuno S. Sperfeld AD. Stoppe G. Kohlhase J. Pickering-Brown S. Neary D. Bugiani O. Wszolek ZK. The effect of tau genotype on clinical features in FTDP-17.  Parkinsonism & Related Disorders. 11(4):205-8, 2005 Jun.
  3. Zaidi SI. Richardson SL. Capellari S. Song L. Smith MA. Ghetti B. Sy MS. Gambetti P. Petersen RB. Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.  Journal of Alzheimer's Disease. 7(2):159-71; discussion 173-80, 2005 Apr.
  4. Boeve BF. Tremont-Lukats IW. Waclawik AJ. Murrell JR. Hermann B. Jack CR Jr. Shiung MM. Smith GE. Nair AR. Lindor N. Koppikar V. Ghetti B. Longitudinal characterization of two siblings with frontotemporal dementia and parkinsonism linked to chromosome 17 associated with the S305N tau mutation.  Brain. 128(Pt 4):752-72, 2005 Apr.
  5. Gemignani A. Pietrini P. Murrell JR. Glazier BS. Zolo P. Guazzelli M. Ghetti B. Slow wave and REM sleep mechanisms are differently altered in hereditary pick disease associated with the TAU G389R mutation. Archives Italiennes de Biologie. (Italian) 143(1):65-79, 2005 Feb. 
  6. Chiesa R. Piccardo P. Dossena S. Nowoslawski L. Roth KA. Ghetti B. Harris DA. Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.  Proceedings of the National Academy of Sciences of the United States of America. 102(1):238-43, 2005 Jan 4.
  7. Barmada S. Piccardo P. Yamaguchi K. Ghetti B. Harris DA. GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiology of Disease. 16(3):527-37, 2004 Aug.
  8. Vidal R. Delisle MB. Ghetti B. Neurodegeneration caused by proteins with an aberrant carboxyl-terminus.  Journal of Neuropathology & Experimental Neurology. 63(8):787-800, 2004 Aug.
  9. Woodruff BK. Baba Y. Hutton ML. Wszolek ZK. Tsuboi Y. Kobayashi T. Ghetti B. Arima K. Yasuda M. Rascol O. Haplotype-phenotype correlations in kindreds with the N279K mutation in the tau gene. Archives of Neurology. 61(8):1327; author reply 1327, 2004 Aug.
  10. Takao M. Ghetti B. Yoshida H. Piccardo P. Narain Y. Murrell JR. Vidal R. Glazier BS. Jakes R. Tsutsui M. Spillantini MG. Crowther RA. Goedert M. Koto A. Early-onset dementia with Lewy bodies.  Brain Pathology. 14(2):137-47, 2004 Apr.
  11. Notari S. Capellari S. Giese A. Westner I. Baruzzi A. Ghetti B. Gambetti P. Kretzschmar HA. Parchi P. Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.  Journal of Biological Chemistry. 279(16):16797-804, 2004 Apr 16.
  12. Vitali A. Piccini A. Borghi R. Fornaro P. Siedlak SL. Smith MA. Gambetti P. Ghetti B. Tabaton M. Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.  Journal of Alzheimer's Disease. 6(1):45-51, 2004 Feb.
  13. Roher AE. Kokjohn TA. Esh C. Weiss N. Childress J. Kalback W. Luehrs DC. Lopez J. Brune D. Kuo YM. Farlow M. Murrell J. Vidal R. Ghetti B. The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.  Journal of Biological Chemistry. 279(7):5829-36, 2004 Feb 13.
  14. Tofaris GK. Razzaq A. Ghetti B. Lilley KS. Spillantini MG. Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.  Journal of Biological Chemistry. 278(45):44405-11, 2003 Nov 7.
  15. De Michele G. Pocchiari M. Petraroli R. Manfredi M. Caneve G. Coppola G. Casali C. Sacca F. Piccardo P. Salvatore E. Berardelli A. Orio M. Barbieri F. Ghetti B. Filla A. Variable phenotype in a P102L Gerstmann-Straussler-Scheinker Italian family. Canadian Journal of Neurological Sciences. 30(3):233-6, 2003 Aug.
  16. Powers JM. Byrne NP. Ito M. Takao M. Yankopoulou D. Spillantini MG. Ghetti B. A novel leukoencephalopathy associated with tau deposits primarily in white matter glia.  Acta Neuropathologica. (Italian) 106(2):181-7, 2003 Aug.
  17. Chiesa R. Piccardo P. Quaglio E. Drisaldi B. Si-Hoe SL. Takao M. Ghetti B. Harris DA. Molecular distinction between pathogenic and infectious properties of the prion protein.  Journal of Virology. 77(13):7611-22, 2003 Jul.
  18. Vidal R. Ghetti B. Takao M. Brefel-Courbon C. Uro-Coste E. Glazier BS. Siani V. Benson MD. Calvas P. Miravalle L. Rascol O. Delisle MB. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.  Journal of Neuropathology & Experimental Neurology. 63(4):363-80, 2004 Apr.
  19. Harris DA. Chiesa R. Drisaldi B. Quaglio E. Migheli A. Piccardo P. Ghetti B. A murine model of a familial prion disease.  Clinics in Laboratory Medicine. 23(1):175-86, 2003 Mar.
  20. Ghetti B. Tagliavini F. Takao M. Bugiani O. Piccardo P. Hereditary prion protein amyloidoses.  Clinics in Laboratory Medicine. 23(1):65-85, viii, 2003 Mar.
  21. Vidal R. Delisle MB. Rascol O. Ghetti B. Hereditary ferritinopathy.  Journal of the Neurological Sciences. 207(1-2):110-1, 2003 Mar 15. 
  22. B. Ghetti, P. Piccardo (Eds.), Clinics in Laboratory Medicine: Prion Diseases. Elsevier Science (USA), Philadelphia, PA, pp. 65-85, 2003.
  23. Ghetti, B.; Takao, M.; Yazaki, M.; Farlow, M.R.; Unverzagt, F.W.; Piccardo, P.; Murrell, J.R.; Benson, M.D. Neuropathology at the crossroad of neuropsychiatry and genetics: new insights into neuroserpin encephalopathy. IN: R. Ragaini (Ed.), International Seminar on Nuclear War and Planetary Emergencies, 27th Session, Pp. 550-567, 2003.
  24. Ghetti, B.; Tagliavini, F.; Bugiani, O.; Piccardo, P.: Gerstmann-Sträussler-Scheinker disease. IN: D. Dickson (Ed.) Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders Pp. 318-325.
  25. Ghetti, B.; Hutton, M.; Wszolek, Z.K. Frontotemporal dementia and Parkinsonism linked to chromosome 17 associated with Tau gene mutations (FTDP-17T). IN: D. Dickson (Ed.) Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders Pp. 86-102.

ABSTRACTS:

  1. Murrell JR, Faber K, Alonso ME, Rasmussen A, Varpetian A, Macias MA, Cochran E, Gambetti P, Castellani RJ, Bauserman SC, Foroud T, Vidal R, Miravalle L, Ghetti B, Ringman JM. The A431E Presenilin 1 gene mutation associated with familial Alzheimer disease in individuals of Mexican descent: evidence for a founder effect. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  2. Yamaguchi K, Miravalle L, Piccardo P, Murrell JR, Foroud T, Vidal R, Unverzagt FW, Farlow MR, Ghetti B. Pheotypic variability associated with the Presenilin 2 N141I mutation in individuals of Volga-German descent. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  3. Hattab EM, Murrell JR, Yamaguchi K, Unverzagt FW, Foroud T, Miravalle L, Takao M, Hullette C, Vidal R, Farlow MR, Ghetti B. :Widespread Aβ angiopathy, cotton wool plaques and pyramidal tract degeneration are the main neuropathologic features associated with the V261F mutation in the Presenilin 1 gene. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  4. Bugiani O, Giaccone G, Capobianco R, Tagliavini F, Ghetti B. Alzheimer disease (AD): AT8 recognizes degenerating ectopic neurons and astrocytes in the subcortical white matter. Journal of Neuropathology and Experimental Neurology. 62:547, 2003.
  5. Delisle MB, Haik S, Uro-Coste E, Peoc.h K, Puel M, Revesz T, Piccardo P, Hauw JJ, Duyckaerts C, Laplanche JL, Ghetti B. Gerstmann-Sträussler-Scheinker disease presenting as corticobasal degeneration.  Journal of Neuropathology and Experimental Neurology 62:548, 2003.
  6. Lee J, Piccardo P, Wilson JA, Fisher M, William A, Ghetti B. Creutzfeldt Jakob disease with prolonged course and Kuru plaques. Journal of Neuropathology and Experimental Neurology 62:549, 2003.
  7. Vidal R, Azzarelli B, Miravalle L, Olson J, Nukes T, Biller J, Ghetti B. CADASIL in two North American Caucasian families. Journal of Neuropathology and Experimental Neurology 62:568, 2003.
  8. Ghetti B, Dickson D, Rascol O, Tsuboi Y, Murrell JR, Wszolek Z, Delisle MB. Diffuse loss of myelin in FTDP-17 associated with mutation N279K in the Tau gene. Journal of Neuropathology and Experimental Neurology 62:583 , 2003.
  9. Bugiani O, Giaccone G, Capobianco R, Tagliavini F, Ghetti B. Alzheimer disease (AD): AT8 recognizes degenerating ectopic neurons and astrocytes in the subcortical white matter. Clinical Neuropathology 22:142, 2003.

Distinguished Professor of Neuropathology
Distinguished Professor of Pathology and Laboratory Medicine
Indiana University School of Medicine
Director, Indiana Alzheimer Center
Clarian Pathology Laboratory
350 West 11th Street, Room 4034
Indianapolis, IN 46202-4108

Telephone: 317-491-6360
FAX: 317-274-4882
email: bghetti@iupui.edu

Over the past 25 years, I have been studying hereditary neurodegenerative diseases of mice and men. My colleagues and I have expertise in neuropathology, biochemistry, and molecular genetics as well as cellular and molecular biology; these disciplines and the relevant techniques are used in a multidisciplinary approach to our research.

We have been focusing on the biology of hereditary dementing disorders, including Alzheimer disease, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and Pick disease. Our studies of kindreds with dementia inherited in an autosomal dominant pattern have resulted in the identification of novel mutations in the Amyloid Precursor Protein, Presenilin 1, Prion Protein, and Tau genes. In addition, we have characterized the clinical, neuropathologic and biochemical phenotypes associated with specific mutations. We also have a long-standing involvement with the analysis of the biology of cell death in neurological mutant mice.

Our current efforts are directed toward the identification, characterization and classification of new forms of dementia and the associated genetic defect. In addition, we are involved in the development and analysis of transgenic mouse models. Clinical and research efforts are funded by multiple grants from the Nation Institutes of Health and the Alzheimer's Association and we have one of the 28 Alzheimer disease centers funded by the National Institute on Aging.

Publications:

  1. Vidal, R.; Ghetti, B.; Takao, M.; Uro-Coste E.; Glazier, B.S.; Siani, V.; Benson, M.D.; Calvas, P.; Miravalle, L.; Rscol, O.; Delisle, M.B. Hereditary Ferritinopathy: A novel neurodegenerative disease associated with a mutation in the Ferritin Light Polypeptide gene and intra cellular ferritin deposition in multiple organ systems. Journal of Neuropathology and Experimental Neurology. (Submitted)
  2. Baba Y. Tsuboi Y. Baker MC. Uitti RJ. Hutton ML. Dickson DW. Farrer M. Putzke JD. Woodruff BK. Ghetti B. Murrell JR. Boeve BF. Petersen RC. Verpillat P. Brice A. Delisle MB. Rascol O. Arima K. Dysken MW. Yasuda M. Kobayashi T. Sunohara N. Komure O. Kuno S. Sperfeld AD. Stoppe G. Kohlhase J. Pickering-Brown S. Neary D. Bugiani O. Wszolek ZK. The effect of tau genotype on clinical features in FTDP-17.  Parkinsonism & Related Disorders. 11(4):205-8, 2005 Jun.
  3. Zaidi SI. Richardson SL. Capellari S. Song L. Smith MA. Ghetti B. Sy MS. Gambetti P. Petersen RB. Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.  Journal of Alzheimer's Disease. 7(2):159-71; discussion 173-80, 2005 Apr.
  4. Boeve BF. Tremont-Lukats IW. Waclawik AJ. Murrell JR. Hermann B. Jack CR Jr. Shiung MM. Smith GE. Nair AR. Lindor N. Koppikar V. Ghetti B. Longitudinal characterization of two siblings with frontotemporal dementia and parkinsonism linked to chromosome 17 associated with the S305N tau mutation.  Brain. 128(Pt 4):752-72, 2005 Apr.
  5. Gemignani A. Pietrini P. Murrell JR. Glazier BS. Zolo P. Guazzelli M. Ghetti B. Slow wave and REM sleep mechanisms are differently altered in hereditary pick disease associated with the TAU G389R mutation. Archives Italiennes de Biologie. (Italian) 143(1):65-79, 2005 Feb. 
  6. Chiesa R. Piccardo P. Dossena S. Nowoslawski L. Roth KA. Ghetti B. Harris DA. Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.  Proceedings of the National Academy of Sciences of the United States of America. 102(1):238-43, 2005 Jan 4.
  7. Barmada S. Piccardo P. Yamaguchi K. Ghetti B. Harris DA. GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiology of Disease. 16(3):527-37, 2004 Aug.
  8. Vidal R. Delisle MB. Ghetti B. Neurodegeneration caused by proteins with an aberrant carboxyl-terminus.  Journal of Neuropathology & Experimental Neurology. 63(8):787-800, 2004 Aug.
  9. Woodruff BK. Baba Y. Hutton ML. Wszolek ZK. Tsuboi Y. Kobayashi T. Ghetti B. Arima K. Yasuda M. Rascol O. Haplotype-phenotype correlations in kindreds with the N279K mutation in the tau gene. Archives of Neurology. 61(8):1327; author reply 1327, 2004 Aug.
  10. Takao M. Ghetti B. Yoshida H. Piccardo P. Narain Y. Murrell JR. Vidal R. Glazier BS. Jakes R. Tsutsui M. Spillantini MG. Crowther RA. Goedert M. Koto A. Early-onset dementia with Lewy bodies.  Brain Pathology. 14(2):137-47, 2004 Apr.
  11. Notari S. Capellari S. Giese A. Westner I. Baruzzi A. Ghetti B. Gambetti P. Kretzschmar HA. Parchi P. Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.  Journal of Biological Chemistry. 279(16):16797-804, 2004 Apr 16.
  12. Vitali A. Piccini A. Borghi R. Fornaro P. Siedlak SL. Smith MA. Gambetti P. Ghetti B. Tabaton M. Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.  Journal of Alzheimer's Disease. 6(1):45-51, 2004 Feb.
  13. Roher AE. Kokjohn TA. Esh C. Weiss N. Childress J. Kalback W. Luehrs DC. Lopez J. Brune D. Kuo YM. Farlow M. Murrell J. Vidal R. Ghetti B. The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.  Journal of Biological Chemistry. 279(7):5829-36, 2004 Feb 13.
  14. Tofaris GK. Razzaq A. Ghetti B. Lilley KS. Spillantini MG. Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.  Journal of Biological Chemistry. 278(45):44405-11, 2003 Nov 7.
  15. De Michele G. Pocchiari M. Petraroli R. Manfredi M. Caneve G. Coppola G. Casali C. Sacca F. Piccardo P. Salvatore E. Berardelli A. Orio M. Barbieri F. Ghetti B. Filla A. Variable phenotype in a P102L Gerstmann-Straussler-Scheinker Italian family. Canadian Journal of Neurological Sciences. 30(3):233-6, 2003 Aug.
  16. Powers JM. Byrne NP. Ito M. Takao M. Yankopoulou D. Spillantini MG. Ghetti B. A novel leukoencephalopathy associated with tau deposits primarily in white matter glia.  Acta Neuropathologica. (Italian) 106(2):181-7, 2003 Aug.
  17. Chiesa R. Piccardo P. Quaglio E. Drisaldi B. Si-Hoe SL. Takao M. Ghetti B. Harris DA. Molecular distinction between pathogenic and infectious properties of the prion protein.  Journal of Virology. 77(13):7611-22, 2003 Jul.
  18. Vidal R. Ghetti B. Takao M. Brefel-Courbon C. Uro-Coste E. Glazier BS. Siani V. Benson MD. Calvas P. Miravalle L. Rascol O. Delisle MB. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.  Journal of Neuropathology & Experimental Neurology. 63(4):363-80, 2004 Apr.
  19. Harris DA. Chiesa R. Drisaldi B. Quaglio E. Migheli A. Piccardo P. Ghetti B. A murine model of a familial prion disease.  Clinics in Laboratory Medicine. 23(1):175-86, 2003 Mar.
  20. Ghetti B. Tagliavini F. Takao M. Bugiani O. Piccardo P. Hereditary prion protein amyloidoses.  Clinics in Laboratory Medicine. 23(1):65-85, viii, 2003 Mar.
  21. Vidal R. Delisle MB. Rascol O. Ghetti B. Hereditary ferritinopathy.  Journal of the Neurological Sciences. 207(1-2):110-1, 2003 Mar 15. 
  22. B. Ghetti, P. Piccardo (Eds.), Clinics in Laboratory Medicine: Prion Diseases. Elsevier Science (USA), Philadelphia, PA, pp. 65-85, 2003.
  23. Ghetti, B.; Takao, M.; Yazaki, M.; Farlow, M.R.; Unverzagt, F.W.; Piccardo, P.; Murrell, J.R.; Benson, M.D. Neuropathology at the crossroad of neuropsychiatry and genetics: new insights into neuroserpin encephalopathy. IN: R. Ragaini (Ed.), International Seminar on Nuclear War and Planetary Emergencies, 27th Session, Pp. 550-567, 2003.
  24. Ghetti, B.; Tagliavini, F.; Bugiani, O.; Piccardo, P.: Gerstmann-Sträussler-Scheinker disease. IN: D. Dickson (Ed.) Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders Pp. 318-325.
  25. Ghetti, B.; Hutton, M.; Wszolek, Z.K. Frontotemporal dementia and Parkinsonism linked to chromosome 17 associated with Tau gene mutations (FTDP-17T). IN: D. Dickson (Ed.) Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders Pp. 86-102.

ABSTRACTS:

  1. Murrell JR, Faber K, Alonso ME, Rasmussen A, Varpetian A, Macias MA, Cochran E, Gambetti P, Castellani RJ, Bauserman SC, Foroud T, Vidal R, Miravalle L, Ghetti B, Ringman JM. The A431E Presenilin 1 gene mutation associated with familial Alzheimer disease in individuals of Mexican descent: evidence for a founder effect. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  2. Yamaguchi K, Miravalle L, Piccardo P, Murrell JR, Foroud T, Vidal R, Unverzagt FW, Farlow MR, Ghetti B. Pheotypic variability associated with the Presenilin 2 N141I mutation in individuals of Volga-German descent. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  3. Hattab EM, Murrell JR, Yamaguchi K, Unverzagt FW, Foroud T, Miravalle L, Takao M, Hullette C, Vidal R, Farlow MR, Ghetti B. :Widespread Aβ angiopathy, cotton wool plaques and pyramidal tract degeneration are the main neuropathologic features associated with the V261F mutation in the Presenilin 1 gene. Journal of Neuropathology and Experimental Neurology 62:543, 2003.
  4. Bugiani O, Giaccone G, Capobianco R, Tagliavini F, Ghetti B. Alzheimer disease (AD): AT8 recognizes degenerating ectopic neurons and astrocytes in the subcortical white matter. Journal of Neuropathology and Experimental Neurology. 62:547, 2003.
  5. Delisle MB, Haik S, Uro-Coste E, Peoc.h K, Puel M, Revesz T, Piccardo P, Hauw JJ, Duyckaerts C, Laplanche JL, Ghetti B. Gerstmann-Sträussler-Scheinker disease presenting as corticobasal degeneration.  Journal of Neuropathology and Experimental Neurology 62:548, 2003.
  6. Lee J, Piccardo P, Wilson JA, Fisher M, William A, Ghetti B. Creutzfeldt Jakob disease with prolonged course and Kuru plaques. Journal of Neuropathology and Experimental Neurology 62:549, 2003.
  7. Vidal R, Azzarelli B, Miravalle L, Olson J, Nukes T, Biller J, Ghetti B. CADASIL in two North American Caucasian families. Journal of Neuropathology and Experimental Neurology 62:568, 2003.
  8. Ghetti B, Dickson D, Rascol O, Tsuboi Y, Murrell JR, Wszolek Z, Delisle MB. Diffuse loss of myelin in FTDP-17 associated with mutation N279K in the Tau gene. Journal of Neuropathology and Experimental Neurology 62:583 , 2003.
  9. Bugiani O, Giaccone G, Capobianco R, Tagliavini F, Ghetti B. Alzheimer disease (AD): AT8 recognizes degenerating ectopic neurons and astrocytes in the subcortical white matter. Clinical Neuropathology 22:142, 2003.

Dept. of Pathology & Laboratory Medicine Administration Office | Van Nuys Medical Science Building | 635 Barnhill Drive, room A-128 | Indianapolis, IN 46202 Indiana University Health Pathology Laboratory: 350 W. 11th Street, Indianapolis, Indiana 46202