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Liang Cheng, MD

Associate Professor of Pathology and Laboratory Medicine
Indiana University School of Medicine
IU Health Pathology Laboratory
350 West 11th Street, Room 4010
Indianapolis, IN 46202-4108
Telephone: (317) 491-6442
FAX: (317) 491-6419
email: lcheng@iupui.edu

Advances in molecular and cellular biology of prostate tumors have lead to development of new therapeutic strategies for advanced prostate cancer. Our current research focuses on development of an effective gene therapy for prostate cancer in animal model systems. We are studying the dendritic cell based immunogene therapy in the mouse prostate reconstitution system. Our laboratory is also testing cytokines, biological response modifiers, suicidal genes, and antiangiogenic agents for their potential antitumor effect in our animal models.

Short-term projects focusing on molecular genetics and biological predictors of genitourinary cancers are available.

Publications:

  1. Eichelberger LE, Cheng L: Does pT2b cancer exist?  Critical appraisal of the 2002 tumor-nodes-metastasis (TNM) classification of prostate cancer. Cancer (in press).

  2. Eichelberger LE, Koch MO, Eble JN, Ulbright TM, Daggy J, Cheng L: Maximum tumor diameter is an independent predictor of prostate specific antigen recurrence in prostate cancer (submitted).

  3. Gupta A, Wang HL, Policarpio-Nicolas, ML, Tretiakova MS, Papavero V, Pins MR, Jiang Z, Humphrey PA, Cheng L, Yang XJ: Expression of alpha-methylacyl-coenzyme racemase in nephrogenic adenoma. Am J Surg Pathol (in press).

  4. Kernek KM. Koch MO. Daggy JK. Juliar BE. Cheng L. The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence.  Journal of Clinical Pathology. 58(7):725-8, 2005 Jul.

  5. Beck SD. Foster RS. Bihrle R. Cheng L. Ulbright TM. Donohue JP. Impact of the number of positive lymph nodes on disease-free survival in patients with pathological stage B1 nonseminomatous germ cell tumor.  Journal of Urology. 174(1):143-5, 2005 Jul.

  6. Jones TD. Eble JN. Cheng L. Application of molecular diagnostic techniques to renal epithelial neoplasms. Clinics in Laboratory Medicine. 25(2):279-303, 2005 Jun.

  7. Cheng L. Jones TD. McCarthy RP. Eble JN. Wang M. MacLennan GT. Lopez-Beltran A. Yang XJ. Koch MO. Zhang S. Pan CX. Baldridge LA; Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma. American Journal of Pathology. 166(5):1533-9, 2005 May.

  8. Cheng L. Koch MO. Juliar BE. Daggy JK. Foster RS. Bihrle R. Gardner TA. The combined percentage of Gleason patterns 4 and 5 is the best predictor of cancer progression after radical prostatectomy.  Journal of Clinical Oncology. 23(13):2911-7, 2005 May 1.

  9. Pan CX. Yang XJ. Lopez-Beltran A. MacLennan GT. Eble JN. Koch MO. Jones TD. Lin H. Nigro K. Papavero V. Tretiakova M. Cheng L. c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications.  Modern Pathology. 18(3):320-3, 2005 Mar.

  10. Hattab EM. Tu PH. Wilson JD. Cheng L. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. American Journal of Surgical Pathology. 29(3):368-71, 2005 Mar.

  11. Poulos CK. Daggy JK. Cheng L. Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites.  Modern Pathology. 18(2):228-34, 2005 Feb.

  12. Emerson RE. Koch MO. Daggy JK. Cheng L. Closest distance between tumor and resection margin in radical prostatectomy specimens: lack of prognostic significance.  American Journal of Surgical Pathology. 29(2):225-9, 2005 Feb.

  13. Kernek KM. Brunelli M. Ulbright TM. Eble JN. Martignoni G. Zhang S. Michael H. Cummings OW. Cheng L. Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors.  Modern Pathology. 17(11):1309-13, 2004 Nov.

  14. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry.  Cancer. 101(9):2006-10, 2004 Nov 1.

  15. Cheng L. Thomas A. Roth LM. Zheng W. Michael H. Karim FW. OCT4: a novel biomarker for dysgerminoma of the ovary.  American Journal of Surgical Pathology. 28(10):1341-6, 2004 Oct.

  16. McCarthy RP. Zhang S. Bostwick DG. Qian J. Eble JN. Wang M. Lin H. Cheng L. Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate.  American Journal of Pathology. 165(4):1395-400, 2004 Oct.

  17. Poulos CK. Koch MO. Eble JN. Daggy JK. Cheng L. Bladder neck invasion is an independent predictor of prostate-specific antigen recurrence.  Cancer. 101(7):1563-8, 2004 Oct 1.

  18. Ulbright TM. Henley JD. Cummings OW. Foster RS. Cheng L. Cystic trophoblastic tumor: a nonaggressive lesion in postchemotherapy resections of patients with testicular germ cell tumors.  American Journal of Surgical Pathology. 28(9):1212-6, 2004 Sep.

  19. Cheng L. Pan CX. Yang XJ. Lopez-Beltran A. MacLennan GT. Lin H. Kuzel TM. Papavero V. Tretiakova M. Nigro K. Koch MO. Eble JN. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients.  Cancer. 101(5):957-62, 2004 Sep 1.

  20. Sweeney C. Li L. Shanmugam R. Bhat-Nakshatri P. Jayaprakasan V. Baldridge LA. Gardner T. Smith M. Nakshatri H. Cheng L. Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.  Clinical Cancer Research. 10(16):5501-7, 2004 Aug 15.

  21. Poulos CK. Daggy JK. Cheng L. Prostate needle biopsies: multiple variables are predictive of final tumor volume in radical prostatectomy specimens. [Journal Article] Cancer. 101(3):527-32, 2004 Aug 1.

  22. Cheng L. Zhang S. Sweeney CJ. Kao C. Gardner TA. Eble JN. Androgen withdrawal inhibits tumor growth and is associated with decrease in angiogenesis and VEGF expression in androgen-independent CWR22Rv1 human prostate cancer model.  Anticancer Research. 24(4):2135-40, 2004 Jul-Aug.

  23. Jones TD. Ulbright TM. Eble JN. Baldridge LA. Cheng L. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma.  American Journal of Surgical Pathology. 28(7):935-40, 2004 Jul.

  24. Cheng L. MacLennan GT. Zhang S. Wang M. Pan CX. Koch MO. Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder. [Journal Article] Cancer. 101(1):183-8, 2004 Jul 1.

  25. Hong H. Kao C. Jeng MH. Eble JN. Koch MO. Gardner TA. Zhang S. Li L. Pan CX. Hu Z. MacLennan GT. Cheng L. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. Cancer. 101(1):83-9, 2004 Jul 1

  26. Cheng L. Paterson RF. Beck SD. Parks J; Prostatic intraepithelial neoplasia: an update.  Clinical Prostate Cancer. 3(1):26-30, 2004 Jun. 

  27. .Eichelberger LE. Cheng L. Does pT2b prostate carcinoma exist? Critical appraisal of the 2002 TNM classification of prostate carcinoma. Cancer. 100(12):2573-6, 2004 Jun 15.

  28. Arora R. Koch MO. Eble JN. Ulbright TM. Li L. Cheng L. Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate.  Cancer. 100(11):2362-6, 2004 Jun 1.

  29. Emerson RE. Ulbright TM. Zhang S. Foster RS. Eble JN. Cheng L. Nephroblastoma arising in a germ cell tumor of testicular origin.  American Journal of Surgical Pathology. 28(5):687-92, 2004 May.

  30. Cheng L. Pan CX. Zhang JT. Zhang S. Kinch MS. Li L. Baldridge LA. Wade C. Hu Z. Koch MO. Ulbright TM. Eble JN. Loss of 14-3-3sigma in prostate cancer and its precursors.  Clinical Cancer Research. 10(9):3064-8, 2004 May 1.

  31. Pan CX. Kinch MS. Kiener PA. Langermann S. Serrero G. Sun L. Corvera J. Sweeney CJ. Li L. Zhang S. Baldridge LA. Jones TD. Koch MO. Ulbright TM. Eble JN. Cheng L. PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.  Clinical Cancer Research. 10(4):1333-7, 2004 Feb 15.

  32. Cheng L. MacLennan GT. Pan CX. Jones TD. Moore CR. Zhang S. Gu J. Patel NB. Kao C. Gardner TA. Allelic loss of the active X chromosome during bladder carcinogenesis.  Archives of Pathology & Laboratory Medicine. 128(2):187-90, 2004 Feb.

  33. Kernek KM. Ulbright TM. Zhang S. Billings SD. Cummings OW. Henley JD. Michael H. Brunelli M. Martignoni G. Foster RS. Eble JN. Cheng L. Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis. American Journal of Pathology. 163(6):2477-84, 2003 Dec.

  34. Zeng G. Hu Z. Kinch MS. Pan CX. Flockhart DA. Kao C. Gardner TA. Zhang S. Li L. Baldridge LA. Koch MO. Ulbright TM. Eble JN. Cheng L. High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia.  American Journal of Pathology. 163(6):2271-6, 2003 Dec.

  35. Paterson RF. Ulbright TM. MacLennan GT. Zhang S. Pan CX. Sweeney CJ. Moore CR. Foster RS. Koch MO. Eble JN. Cheng L. Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma.  Cancer. 98(9):1830-6, 2003 Nov 1.

  36. Brunelli M. Eble JN. Zhang S. Martignoni G. Cheng L. Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma.  Modern Pathology. 16(10):1060-3, 2003 Oct.

  37. Brunelli M. Eble JN. Zhang S. Martignoni G. Cheng L. Gains of chromosomes 7, 17, 12, 16, and 20 and loss of Y occur early in the evolution of papillary renal cell neoplasia: a fluorescent in situ hybridization study.  Modern Pathology. 16(10):1053-9, 2003 Oct.

  38. Brandli DW. Ulbright TM. Foster RS. Cummings OW. Zhang S. Sweeney CJ. Eble JN. Cheng L. Stroma adjacent to metastatic mature teratoma after chemotherapy for testicular germ cell tumors is derived from the same progenitor cells as the teratoma.  Cancer Research. 63(18):6063-8, 2003 Sep 15.

  39. Eichelberger LE. Koch MO. Daggy JK. Ulbright TM. Eble JN. Cheng L. Predicting tumor volume in radical prostatectomy specimens from patients with prostate cancer.  American Journal of Clinical Pathology. 120(3):386-91, 2003 Sep.

  40. Younger C. Ulbright TM. Zhang S. Billings SD. Cummings OW. Foster RS. Eble JN. Cheng L. Molecular evidence supporting the neoplastic nature of some epidermoid cysts of the testis. Archives of Pathology & Laboratory Medicine. 127(7):858-60, 2003 Jul.

  41. Siqueria TM Jr. Paterson RF. Kuo RL. Kaefer M. Cheng L. Shalhav AL. Laparoscopic ileocytoplasty and continent ileovesicostomy in a porcine model.  Journal of Endourology. 17(5):301-5, 2003 Jun.

  42. Zhang S. Zeng G. Wilkes DS. Reed GE. McGarry RC. Eble JN. Cheng L. Dendritic cells transfected with interleukin-12 and pulsed with tumor extract inhibit growth of murine prostatic carcinoma in vivoProstate. 55(4):292-8, 2003 Jun 1.

  43. Hong H. Koch MO. Foster RS. Bihrle R. Gardner TA. Fyffe J. Ulbright TM. Eble JN. Cheng L. Anatomic distribution of periprostatic adipose tissue: a mapping study of 100 radical prostatectomy specimens.  Cancer. 97(7):1639-43, 2003 Apr 1.

  44. Fouts RL. Sandusky GE. Zhang S. Eckert GJ. Koch MO. Ulbright TM. Eble JN. Cheng L. Down-regulation of fragile histidine triad expression in prostate carcinoma.  Cancer. 97(6):1447-52, 2003 Mar 15.

  45. Paterson RF. Barret E. Siqueira TM Jr. Gardner TA. Tavakkoli J. Rao VV. Sanghvi NT. Cheng L. Shalhav AL. Laparoscopic partial kidney ablation with high intensity focused ultrasound.  Journal of Urology. 169(1):347-51, 2003 Jan.

  46. Lopez-Beltran A, Cheng L: Stage pT1 bladder carcinoma: diagnostic criteria, pitfalls, and diagnostic significance. Pathology 35:484-491, 2003.

BOOKS:

Cheng L and Bostwick DG (ed): Essentials of Anatomic Pathology. Totowa, New Jersey: Humana Press, 2002 (total number of pages, 940; author of 5 chapters).  Bestseller of the publisher

BOOK CHAPTERS:

  1. Emerson RE, Cheng L and Ulbright TM: Chapter 14. Endocrine testis. In RV Lloyd (ed) Endocrine Pathology: Differential Diagnosis and Molecular Advances page 267-278, Totowa, NJ: Humana Press, 2003.

  2. Emerson RE, Ulbright TM, Eble JN, Cheng L:  Urinary tract and male genital system. In CR Taylor and RJ Cote (eds) Molecular Morphology and Immunomicroscopy (Major Problems in Pathology Vol 19).  New York, NY, Elsevier Science, 2004 (in press).

  3. Authors of multiple chapters on World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds). See page 134, 138, 145, 146, 199, 209, 213, 214. IARC Press, Lyon, 2004.

  4. Author of multiple chapters on World Health Organization Classification of Tumors of Endocrine Organs, IARC Press, Lyon, 2004 (in press).

 

REFEREED ABSTRACTS:

  1. Arora R, Ulbright TM, Koch MO, Eble JN, Cheng L: Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 634A, 2003.

  2.  Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Bonetti F, Cheng L: Detection of loss of 2 or more of chromosome 1,2,6,10 and 17 by fluorescence in situ hybridization effectively distinguishes eosinophilic chromophobe renal cell carcinoma from renal oncocytoma. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 650A, 2003.

  3.  Brunelli M, Eble JN, Zhang S, Martignoni G, Cheng L: Metanephric adenoma lacks the gain of chromosomes 7 and 17 and loss of Y which are typical of papillary renal cell carcinoma and adenoma. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 651A, 2003.

  4.  Brunelli M, Eble JN, Zhang S, Martignoni G, Cheng L: Gains of chromosomes 7, 17, 12, 16 and 20, and loss of Y occur early in the evolution of papillary renal cell neoplasia: a fluorescent in situ hybridization study of papillary adenoma from autopsies. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 652A, 2003.

  5.  Cheng L, Brandli DW, Ulbright TM, Foster RS, Cummings OW, Zhang S, Eble JN:  Stroma adjacent to metastatic mature teratoma after chemotherapy for testicular germ cell tumor is derived from the same progenitor cells as the teratoma. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 658A, 2003.

  6.  Eble JN, Brunelli M, Cheng L, Zhang S, Martignoni G: Eosinophilic renal tumors with indeterminate reactions with Hale's colloidal iron stain have genetic abnormalities not found in renal oncocytoma. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 669A, 2003.

  7.  Martignoni G, Eble JN, Cheng L, Pea M: Chromophobe renal cell carcinoma: a clinicopathologic study of 100 cases.  Modern Pathology 16: 735A, 2003.

  8.  Fouts RL, Sandusky GE, Zhang S, Eckert GJ, Koch MO, Ulbright TM, Eble JN, Cheng L: Down regulation of FHIT expression in prostatic carcinoma. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 679A, 2003.

  9.  Kernek KM, Brunelli M, Ulbright TM, Michael H, Cummings OW, Zhang S, Martignoni G, Eble JN, Cheng L: Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 713A, 2003.

  10.  Kernek KM, Zhang S, Ulbright TM, Billings SD, Cummings OW, Henley JD, Michael H,  Zhang S, Brunelli M, Martignoni G, Eble JN, Cheng L: Identical allelic loss in mature teratoma and different histologic components of malignant mixed germ cell tumors of the testis. Presented at the 2003 annual meeting of the United States and Canadian Academy of Pathology in Washington DC.  Modern Pathology 16: 714A, 2003.

  11.  Gardner TA, Lee SJ, Mosharafa A, Lee X, Yu R, Cheng L, Kim HS, Jung C, Kao C: Generation of a prostate-restricted replication competent adenovirus using a chimeric prostate-specific promoter. Presented at the 98th annual meeting of the American Urological Association, Chicago, IL. Journal of Urology 169: 830A, 2003.

  12.  Cheng L, Brandli DW, Zhang S, Ulbright TM, Sweeney CJ, Eble JN:  Concordant genetic alterations in teratoma and stroma adjacent to metastatic mature teratoma after chemotherapy for testicular cancer. Presented at the 94th annual meeting of the American Association for Cancer Research in Washington DC.  Proceedings of the American Association of Cancer Research (2nd ed.), 44: 3529A, 2003.

  13.  Cheng L, Fouts RL, Sandusky GE, Zhang S, Eble JN: FHIT expression in prostate cancer. Presented at the 94th annual meeting of the American Association for Cancer Research in Washington DC.  Proceedings of the American Association of Cancer Research (2nd ed.), 44: 5419A, 2003.

  14.  Armatys S, Koch MO, Bihrle R, Gardner TA, Eble JN, Patel NB, Daggy JB, Cheng L: A clinicopathologic comparison of clinical sages T1c versus T2 prostate adenocarcinoma: lack of difference in PSA recurrence. Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 573A, 2004.

  15.  Barbarin A, Cheng L: Anatomic distribution and pathologic characterization of small volume prostate cancer (<0.5cc) in whole-mount prostatectomy specimens.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 582A, 2004.

  16.  Bunde PJ, Koch MO, Bihrle RA, Gardner TA, Eble JN, Daggy J, Cheng L: Preoperative PSA is correlated with tumor volume and prostate weight and predictive of PSA recurrence.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 596A, 2004.

  17.  Carr MD, Abraham S, Cheng L, Kinch M, Knapp D, Mohammed S: EphA2:  a novel target for the treatment of bladder cancer.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 600A, 2004.

  18.  Carr MD, Koch MO, Eble JN, Zeng G, Daggy J, Cheng L: Vascular invasion is an independent prognostic factor in prostatic adenocarcinoma.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 601A, 2004.

  19.  Cheng L, Koch MO, Daggy J:  The combined percentage of Gleason 4 and 5 is the best predictor of cancer progression after radical prostatectomy.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 603A, 2004.

  20.  Cheng L, Koch MO, Poulos CK, Jones TD, Daggy JK:  Preoperative prediction of small volume cancer (<0.5cc) in radical prostatectomy specimens.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 604A, 2004.

  21.  Cheng L: Diagnosing metastatic germ cell tumors using OCT4 immunohistochemistry. Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 605A, 2004.

  22.  Eichelberger LE, Koch MO, Eble JN, Ulbright TM, Daggy J, Cheng L: Maximum tumor diameter is an independent predictor of prostate specific antigen recurrence in prostate cancer.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 618A, 2004.

  23.  Eichelberger LE, Cheng L: Does pT2b cancer exist?  Critical appraisal of the 2002 tumor-nodes-metastasis (TNM) classification of prostate cancer:  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 619A, 2004.

  24.  Emerson RE, Koch MO, Daggy J, Cheng L:  Closest distance between tumor and resection margin in radical prostatectomy specimens:  does it matter? Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 622A, 2004.

  25.  Emerson RE, Koch MO, Daggy J, Cheng L:  The significance of extent of surgical margin positivity on prostate specific antigen recurrence.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 623A, 2004.

  26.  Hong H, Kao C, Jeng M, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Hu Z, MacLennan GT, Cheng L:  Overexpression of CARM1, a transcriptional coactivator of androgen receptor, in prostatic adenocarcinoma and its precursors.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 660A, 2004.

  27.  Jones TD, Ulbright TM, Eble JN, Cheng L:  OCT4 is a sensitive and specific marker for testicular seminoma and embryonal carcinoma.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 670A, 2004.

  28.  Jones TD, Zhang S, Eble JN, MacLennan GT, Huffman S, Cheng L:  Genetic heterogeneity in renal cell carcinomas with clear cell and sarcomatoid components.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 671A, 2004.

  29.  Jones TD, Ulbright TM, Eble JN, Cheng L:  OCT4 Immunostaining is useful in the diagnosis of intratubular germ cell neoplasia.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 672A, 2004.

  30.  Kernek KM, Koch MO, Moore CR, Patel NB, Daggy J, Cheng L:  The presence of benign prostatic glandular tissue at surgical margins does not predict PSA recurrence.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 678A, 2004.

  31.  McCarthy RP, Zhang S, Bostwick DG, Qian J, Eble JN, Cheng L:  Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 697A, 2004.

  32.  McCarthy RP, Zhang S, Eble JN, Lopez-Beltran A, Yang XJ, MacLennan GT, Nigro K, Pan C, Huffman S, Cheng L: Concordant genetic alterations in the urinary bladder small cell carcinomas and co-existing urothelial carcinoma.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 698A, 2004.

  33.  Pan C, Lopez-Beltran A, Yang XJ, MacLennan GT, Eble JN, Cheng L:  Small cell carcinoma of the urinary bladder:  a report of 52 cases.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 713A, 2004.

  34.  Pan CX, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, Cheng L:  PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 714A, 2004.

  35.  Poulos C, Daggy JK, Cheng L:  Prostate needle biopsies: multiple variables are predictive of final tumor volume in radical prostatectomy specimen.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 723A, 2004.

  36.  Poulos CK, Koch MO, Eble JN, Cheng L:  The significance of bladder neck invasion in radical prostatectomy specimens:  evidence supporting the current TNM staging system.   Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 724A, 2004.

  37.  Poulos CK, Daggy J, Cheng L:  Preoperative prediction of gleason grade in radical prostatectomy specimens.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 725A, 2004.

  38. Sweeney C, Li L, Bhat-Nakshatri P,  Baldridge LA, Zhang S, Gardner T, Kao C, Koch MO, Nakshatri H, Cheng L:  Nuclear factor kappa b is constitutively activated in prostate cancer in vitro and is increased in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 750A, 2004.

  39. Zeng G, Hu Z, Zhang S, Li L, Baldridge LA, Koch MO, Ulbright TM, Eble JN, Cheng L:  Expression of EphA2 receptor tyrosine kinase is elevated in prostatic intraepithelial neoplasia and prostatic cancer.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 781A, 2004.

  40. Zhang S, Pan C, Li L, Wade C, Hu Z, Koch MO, Ulbright TM, Eble JN, Cheng L: Loss of 14-3-3s in prostate adenocarcinoma and its precursors.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 784A, 2004.

  41. Liang SX, Zhang JT, Cheng L, Zhang S, Zheng W:  Endometrial gladular dysplasia, a newly defined precursor lesion of uterine papillary serous carcinoma:  a molecular study.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 848A, 2004.

  42. Sever MD, Karim A, Zheng WM, Roth LM, Michael H, Cheng L:  Expressions of CD117 (c-kit) receptor in dysgerminoma.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 898A, 2004.

  43. Thomas A, Roth LM, Abdul-Karim FW, Zheng WM, Michael H, Cheng L:  OCT4:  a specific biomarker for dysgerminoma of the ovary.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 905A, 2004.

  44. Henley JD, Summerlin D-J, Tomich CE, Zhang S, Cheng L:  Molecular evidence supporting the neoplastic nature of odontogenic keratocyst:  a laser capture microdissection study of 15 cases.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 946A, 2004.

  45. Kong G, Czader M, Orazi A, O'Malley D, Zhang S, Cheng L:  High incidence of allelic imbalance in low grade myelodysplastic syndromes:  analysis of archival samples in multiple DNA microsatellite markers.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 1075A, 2004.

  46. Cummings OW, Zhang S, Strate R, Saxena R, Jones TD, Cheng L:  Multifocal hepatocellular carcinoma: independent primaries or intrahepatic metastases.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 1250A, 2004.

  47. Hattab EM, Cheng L:  OCT-4 is preferentially expressed in primary intracranial germinomas of the pineal region.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology17: 1331A, 2004.

  48. Billings SD, Hans CP, Cheng L:  PC cell-derived growth factor (PCDGF) expression in melanocytic tumors:  an analysis of 61 cases.  Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 1353A, 2004.

  49. Hattab EM, Cheng L:  Expression of c-kit (CD117) in primary pineal germinomas. Presented at the 2004 annual meeting of the United States and Canadian Academy of Pathology in Vancouver, B.C., Canada.  Modern Pathology 17: 1362A, 2004. 

Dept. of Pathology & Laboratory Medicine Administration Office | Van Nuys Medical Science Building | 635 Barnhill Drive, room A-128 | Indianapolis, IN 46202 Indiana University Health Pathology Laboratory: 350 W. 11th Street, Indianapolis, Indiana 46202